Blaz Mrevlje
Ljubljana University School of Medicine, Slovenia
Title: Biologic response of a porcine coronary artery to stent implantation
Biography
Biography: Blaz Mrevlje
Abstract
Introduction: Stent implantation in a coronary artery results in mechanical injury of the vessel wall and involves de-endothelisation, stretching and tearing of media and in the case of an atherosclerotic plaque also plaque rupture. These processes are followed by the activation of platelets, thrombus formation and inflammation in the vessel wall. Activated chemokines and cytokines activate the proliferation and migration of smooth muscle cells within the media and from media into intima resulting in hypertrophy of the intima and restenosis of the stented segment of the coronary artery.
Methods: Three groups of young pigs were included in the study and followed-up with optical coherence tomography 14 days, 1 month and 2 months after angiographically-guided stent implantation. Three types of stents (bare-metal - BMS, drug-eluting - DES and multimode - MMS) were implanted in each individual pig in a randomized fashion. All stents were of 3.0 x 15 mm in size.
Results: After 14 days the neointima thickness was 118,77±54,27µm in BMS, 57,15±12,01µm in MMS and 53,04±9,50µm in DES. After 1 month the neointima thickness was 323,02±174,07µm in BMS, 173,46±60,11µm in MMS and 112,08±26,00µm in DES. After 2 months the neointima thickness was 250,25±213,66µm in BMS, 138,86±110,42µm in MMS and 159,55±53,95µm in DES.
Conclusion: Biologic response of a porcine coronary artery in terms of neoitnima thickness to stent implantation is as expected according to stent type and the time of follow-up