Biography
Biography: Jing-song Ou
Abstract
Circulating microparticles are a group of membrane vesicles which are released by cell activation or apoptosis. Previous studies demonstrated that circulating microparticles or certain subgroups of circulating microparticles increased in a variety of cardiovascular diseases, such as hypertension, acute coronary syndromes and mitral valve disease. Vascular function is very important for maintaining circulation after cardiac surgery. However, the impact of microparticles generated from patients with valvular heart disease before and after cardiac surgery on vascular function remains unknown. Therefore, we investigated if circulating microparticles from valvular heart disease patients undergoing cardiac surgery would lead to vascular dysfunction. We found that circulating microparticles from valvular heart disease patients could impair endothelium-dependent vasodilation by decreasing nitric oxide production and increasing superoxide anion generation, which was caused by uncoupling endothelial nitric oxide synthase and inhibition of its activity. As this effect was more prominent during perioperative period after cardiac surgery, hemodynamic abnormality might be induced. Our findings suggested that circulating microparticles might be potential therapeutic targets for maintaining vascular function after cardiac surgery